Male breast cancer is a disease in which malignant (cancer)
cells form in the tissues of the breast.
Breast cancer may occur in
men. Men at any age may develop breast cancer, but it is usually detected
(found) in men between 60 and 70 years of age. Male breast cancer makes up less
than 1% of all cases of breast cancer.
The following types of breast cancer are found in men:
Lobular carcinoma in
situ (abnormal cells found in one of the
lobes or sections of the breast),
which sometimes occurs in women, has not been seen in men.
Male breast anatomy: Anatomy of the male breast showing the nipple, areola, fatty tissue, and ducts. Nearby lymph nodes, ribs, and muscle are also shown.
Radiation exposure, high levels of estrogen, and a family
history of breast cancer can increase a man’s risk of breast cancer.
Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn’t mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for breast
cancer in men may include the following:
Male breast cancer is sometimes caused by inherited gene
The genes in cells carry the hereditary information that is received from a person’s parents. Hereditary breast cancer makes up about 5% to 10% of all breast cancer. Some mutated genes related to breast cancer are more common in certain ethnic groups.
Men who have a mutated gene related to breast cancer have an increased risk of this disease.
There are tests that can detect (find) mutated genes. These genetic tests are sometimes done for members of families with a high risk of cancer. See the following PDQ summaries for more information:
- Genetics of Breast and Ovarian Cancer
- Breast Cancer Prevention
- Breast Cancer Screening
Men with breast cancer usually have lumps that can be felt.
Lumps and other symptoms may be caused by male breast cancer. Other conditions may cause the same symptoms. Check with your doctor if you notice a change in your breasts.
Tests that examine the breasts are used to detect (find) and diagnose breast cancer in men.
The following tests and procedures may be used:
- Physical exam and history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.
- Clinical breast exam (CBE): An exam of the breast by a doctor or other health professional. The doctor will carefully feel the breasts and under the arms for lumps or anything else that seems unusual.
- Ultrasound exam: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a sonogram. The picture can be printed to be looked at later.
- Blood chemistry studies: A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease in the organ or tissue that makes it.
If cancer is found, tests are done to study the cancer cells.
Decisions about the best treatment are based on the results of these tests. The tests give information about:
Tests include the following:
- How quickly the cancer may grow.
- How likely it is that the cancer will spread through the body.
- How well certain treatments might work.
- How likely the cancer is to recur (come back).
- Estrogen and progesterone receptor test: A test to measure the amount of estrogen and progesterone (hormones) receptors in cancer tissue. If cancer is found in the breast, tissue from the tumor is checked in the laboratory to find out whether estrogen and progesterone could affect the way cancer grows. The test results show whether hormone therapy may stop the cancer from growing.
- HER2 test: A test to measure the amount of HER2 in cancer tissue. HER2 is a growth factor protein that sends growth signals to cells.
When cancer forms, the cells may make too much of the protein, causing more cancer cells to grow. If cancer is found in the breast, tissue from the tumor is checked in the laboratory to find out if there is too much HER2 in the cells. The test results show whether monoclonal antibody therapy may stop the cancer from growing.
Survival for men with breast cancer is similar to survival for
women with breast cancer.
Survival for men with breast cancer is similar to that for women
with breast cancer when their stage
at diagnosis is the same. Breast
cancer in men, however, is often diagnosed at a later stage. Cancer found at a
later stage may be less likely to be cured.
Certain factors affect prognosis
(chance of recovery) and treatment options.
The prognosis (chance of recovery) and treatment options depend on
- The type of breast cancer.
- Estrogen-receptor and progesterone-receptor levels in the tumor tissue.
- Whether the cancer is also found in the other breast.